Zuclopenthixol

Zuclopenthixol

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Antipsychotic Some Weight Gain Risk
Sedating: Can be Driving: Caution QT risk: Moderate Akathisia: Moderate Metabolic: Moderate Prolactin: Moderate t½: 20 h Tmax: 4 h

An old-school thioxanthene antipsychotic. It comes in tablets, but it’s most famous for its depot injections — often used when someone isn’t taking oral meds. There’s even a rapid-acting acetate form sometimes used in acute wards when sedation is needed quickly. It’s heavy on EPS (stiffness, restlessness), and like all the typicals, not exactly gentle. Still used in the UK because it works, but more as a “maintenance/safety net” drug than a first-line choice.

🩺 Main Uses

Schizophrenia; behavioural disturbance requiring depot/rapid control.

🧪 The Science & Facts

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Half‑life (t½)

20 h

How long the drug hangs around. Longer half‑life = slower changes.

Time to Peak (Tmax)

4 h

Roughly when you feel the main effect after a dose.

What it hits (receptors)

Primary:

D2 (antagonist)

How your body processes it (metabolism)

Substrate: CYP2D6

Depot half‑life prolonged; interactions similar to other 2D6 substrates.

⚠️ Warnings

  • EPS, hypotension, anticholinergic effects (less).

⏬ Taper & Withdrawal

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If you’re reducing

For depot, taper via extending interval rather than abrupt stop.

Possible withdrawal

Rebound agitation/insomnia; relapse risk.

Info here is educational, not medical advice. Always taper with prescriber support if possible.

🧠 Trusted External Sources Last reviewed 22 Aug 2025, 21:23 by Connor O’Driscoll

🔗 Interaction Checker

Always verify drug interactions using the Drugs.com Checker.

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⚠️ Black Box Warning

All antipsychotics: ↑ mortality in elderly with dementia‑related psychosis.

This is a plain‑English summary of headline safety warnings. Talk to a clinician before changing any medication.