🩺 Main Uses
Treatment‑resistant depression; social anxiety disorder.
🧪 The Science & Facts
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Half‑life (t½)
11 h
How long the drug hangs around. Longer half‑life = slower changes.
Time to Peak (Tmax)
2 h
Roughly when you feel the main effect after a dose.
What it hits (receptors)
Primary:
Boosts monoamines (5-HT, NE, DA).
How your body processes it (metabolism)
Not CYP-driven; interaction risk is mainly pharmacodynamic.
⚠️ Warnings
- Hypertensive crisis with tyramine foods; life‑threatening interactions with SSRIs, TCAs, tramadol, dextromethorphan.
⏬ Taper & Withdrawal
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If you’re reducing
Introduce slowly; educate on tyramine diet and interaction list. Taper over weeks when stopping.
Possible withdrawal
Insomnia, agitation, mood dip; rare withdrawal if tapered.
Info here is educational, not medical advice. Always taper with prescriber support if possible.
🧠 Trusted External Sources Last reviewed 22 Aug 2025, 21:24 by Connor O’Driscoll
🔗 Interaction Checker
Always verify drug interactions using the Drugs.com Checker.
Need Help Getting Off This?
Try your GP first. If that doesn't help, find local support services who understand tapering.
Find Support Near You →⚠️ Black Box Warning
Contraindicated with many drugs; 2-week washout (5 weeks after fluoxetine) required when switching.
This is a plain‑English summary of headline safety warnings. Talk to a clinician before changing any medication.