Flupentixol

Antipsychotic Some Weight Gain Risk

Sedating: Can be Driving: Caution QT risk: Moderate Akathisia: Moderate Metabolic: Moderate Prolactin: Moderate t½: 35 h Tmax: 3 h

Available in both oral and depot forms. At low doses it can be mildly stimulating (sometimes used in depression), at higher doses it’s a straightforward typical antipsychotic with EPS risks. The depot injection is still used for long-term schizophrenia management. A solid, old-school option — reliable but not gentle.

Uses • Warnings

🩺 Main Uses

Schizophrenia; long‑acting depot for maintenance.

🧪 The Science & Facts

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Half‑life (t½)

35 h

How long the drug hangs around. Longer half‑life = slower changes.

Time to Peak (Tmax)

3 h

Roughly when you feel the main effect after a dose.

What it hits (receptors)

Primary:

D2 (antagonist)

Secondary:

alpha1 (antagonist)

How your body processes it (metabolism)

Substrate: CYP2D6

Monitor with CYP2D6 inhibitors; depot has long tail.

⚠️ Warnings

EPS/akathisia; hypotension.

⏬ Taper & Withdrawal

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If you’re reducing

Taper slowly; depot: dose‑interval adjustments rather than abrupt stop.

Possible withdrawal

Insomnia/anxiety or akathisia rebound possible.

Info here is educational, not medical advice. Always taper with prescriber support if possible.

🧠 Trusted External Sources Last reviewed 22 Aug 2025, 21:23 by Connor O’Driscoll

Drugs.com

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NHS

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🔗 Interaction Checker

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⚠️ Black Box Warning

All antipsychotics: ↑ mortality in elderly with dementia‑related psychosis.

This is a plain‑English summary of headline safety warnings. Talk to a clinician before changing any medication.

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