Clorazepate

Clorazepate

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Benzodiazepine Very Addictive High Abuse Potential
Sedating: Yes Driving: Avoid QT risk: None Akathisia: None Metabolic: Low Prolactin: Low t½: 40 h Tmax: 2 h

An oddball benzo, more common in Europe than the UK. It’s actually a prodrug that turns into nordiazepam (basically a Valium cousin) once in the body. Used for anxiety, seizures, and alcohol withdrawal, but rare to see in NHS prescribing. Think of it as Valium’s less famous, more complicated relative.

Uses • Warnings

🩺 Main Uses

Anxiety; alcohol withdrawal; seizure disorders.

🧪 The Science & Facts

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Half‑life (t½)

40 h

How long the drug hangs around. Longer half‑life = slower changes.

Time to Peak (Tmax)

2 h

Roughly when you feel the main effect after a dose.

What it hits (receptors)

Primary:

GABA-A (positive allosteric modulator)

Rapidly decarboxylated to desmethyldiazepam (long-acting).

How your body processes it (metabolism)

Substrate: CYP3A4

Long-acting metabolite extends effect.

⚠️ Warnings

  • Converted in the body to nordiazepam (long-acting).
  • Similar risks as diazepam but slower onset.
  • Sedation, impaired concentration, and coordination common.
  • Still carries dependence and withdrawal risk.
  • Caution in liver disease (metabolised slowly).

Benzo detected — read this first

Benzodiazepines and Z‑drugs can cause severe dependence and withdrawal. Never stop abruptly.

Street Benzo Warning (UK)

High rates of contamination reported by WEDINOS. Fake Xanax is common.

For tapering, see the Ashton Manual and the TripSit Converter.

💊 Open Benzo Converter

⏬ Taper & Withdrawal

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If you’re reducing

Switch to diazepam if tapering; reduce slowly.

Possible withdrawal

Anxiety, tremor, insomnia, seizures.

Info here is educational, not medical advice. Always taper with prescriber support if possible.

🧠 Trusted External Sources Last reviewed 22 Aug 2025, 21:31 by Connor O’Driscoll

🔗 Interaction Checker

Always verify drug interactions using the Drugs.com Checker.

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⚠️ Black Box Warning

All benzos: dependence, withdrawal seizures, ↑ mortality with opioids.

This is a plain‑English summary of headline safety warnings. Talk to a clinician before changing any medication.